However, several insect species remain unaffected by ecdysteroids present in their food even at high concentrations. These resistant insects have developed effective detoxification/inactivation mechanisms. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. ex Aiton (2.1), eremanthine from Laurus nobilis L. (2.2), 15-methoxypinusolidic acid from Biota orientalis (L.) Endl. Other compounds showing exceptional activity were ajugapitin (184) from Ajuga chamaepitys (Labiatae) and 4,15-dihydroajugapitin from Ajuga pseudoiva, both of which were active at 0.3 ppm against S. littoralis.339 Clerodin and dihydroclerodin are both active at 50 ppm against S. littoralis. Inhibition of parasitaemia was demonstrated in mouse models with P. berghei, supporting the traditional use of the plant against malaria. (1830) =Ajuga bracteosa var. An interestingly different study has concentrated on substances deterrent to leaf-cutting ants. Translation for 'ajuga' in the free English-Dutch dictionary and many other Dutch translations. Indeed, if this is drunk beforehand, it will protect against harm from ingesting a deadly poison. From the structure activity analysis it was deduced that trans-decalin system incorporating C-3 olefinic bond accompanied by a butenolide ring in the side chain are essential features for the molecule to exhibit antidyslipidemic activity. (1E,3R*,4S*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4S*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4R*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (3R*,4S*,5E,7Z)-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4R*,5E,7Z)-1,8-dibromo-3,4-dichloro-3,7-dimethylocta-1,5,7-triene, and (3R*,4S*)-3,4,6,7-tetrachloro-3,7-dimethylocten-1-ene showed greater cytotoxicity (IC50 of 6.6–9.9 µM) than the known cancer drug cisplatin (IC50 of 13 µM) in the cancer cell line [78]. Selected Bioactive Monoterpenes from African Medicinal Plants, Susan G. Wynn, Barbara J. Fougère, in Veterinary Herbal Medicine, 2007. Dalechamps and Bauhin state Musa's recommendation of the herb in warm water as beneficial to those sighing and breathing with difficulty; while the leaves in honey help consumptives, especially those who cough up purulent matter. : From ethnopharmacology to phytomedical perspective in the treatment of malaria, Israili and Lyoussi 2009; Ramazanov 2005; Rharrabe et al. Noun 1. genus Ajuga ... Ajuga remota benth. Later, Imamura et al. Until further research is forthcoming, this former panacea is probably better considered in practice as a tonic, not only of the nervous system but of the digestive system also, owing to its bitter, aromatic and spasmolytic qualities. FAQ. was confirmed in alloxan (150 mg/kg BW) rat model of diabetes also by (Boudjelal et al., 2015). More recently, Muller et al. Antonyms for ajugas. Galen states that betony cleanses the lungs and Serapio repeats this, adding a strengthening action. Clerodane diterpenes are an important diverse class of secondary metabolites characterized by a bicyclic decalin ring system. There are 40 to 45 species found throughout almost the whole world. The relative configuration was assigned on the basis of the X-ray crystallographic analysis of its acetate derivative. (family Cupressaceae Gray) (2.3), ajugalide D from Ajuga ciliata Bunge (2.3), carnosol from by Rosmarinus officinalis L. (2.3), triptolide from Tripterygium wilfordii Hook. 2007). The chemical analysis of the extracts from different parts of A. iva revealed the presence of various bioactive compounds belonging to several phytochemical classes such as flavonoids, terpenoids, steroids and fatty acids (Taleb-Senouci et al., 2009; Aly et al., 2011; Bakrim et al., 2014; Boudjelal et al., 2015; Bendif et al., 2017; Chouitah et al., 2017). Medical Information Search. Copyright © 2020 Elsevier B.V. or its licensors or contributors. ex Vatke : Synonym(s) Heterotypic =Ajuga remota Benth. Although several approaches have been reported for the synthesis of clerodane and related diterpenes [241–243], but only three describe the synthesis of 40. With this study clerodane diterpene emerged as a new class of lipid lowering agent which acts through the inhibition of HMGR as one of the probable mechanistic pathway. The hypoglycaemic activity of different doses of aqueous extracts of the aerial parts of Ajuga iva (L.) Schreb. A large number of compounds have already been isolated from A. remota , including ergosterol-5,8-endoperoxide ( 6 ), ajugarin-I ( 1 ), 8- O -acetylharpagide ( 5 ) and several phytoecdysteroids. A large number of compounds have already been isolated from A. remota, including ergosterol-5,8-endoperoxide (6), ajugarin-I (1), 8-O-acetylharpagide (5) and several phytoecdysteroids. 2007). Also, its absolute stereochemistry was established as 5R, 8R, 9R, 10R at four stereo-centers. It also has 100 catfish and many other herbs and spices. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780124059276000011, URL: https://www.sciencedirect.com/science/article/pii/B978032302998850024X, URL: https://www.sciencedirect.com/science/article/pii/B9780080453828000745, URL: https://www.sciencedirect.com/science/article/pii/B9780080912837000539, URL: https://www.sciencedirect.com/science/article/pii/B9780123983732000029, URL: https://www.sciencedirect.com/science/article/pii/B9780443103445000343, URL: https://www.sciencedirect.com/science/article/pii/S0378874120300283, URL: https://www.sciencedirect.com/science/article/pii/S0944711311003308, URL: https://www.sciencedirect.com/science/article/pii/S0223523417307341, URL: https://www.sciencedirect.com/science/article/pii/S0378874118325017, Monoterpenes and Related Compounds from the Medicinal Plants of Africa, Michel Kenne Tchimene, ... Victor Kuete, in, Veterinary Herbal Medicine: A Systems-Based Approach, Development & Modification of Bioactivity, Azucena Gonzalez-Coloma, ... Braulio M. Fraga, in, Miscellaneous Natural Products Including Marine Natural Products, Pheromones, Plant Hormones, and Aspects of Ecology, Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases, Graeme Tobyn BA FHEA FNIMH, ... Margaret Whitelegg BA PhD FNIMH, in, Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Ajuga iva (L.,) schreb, Abdelhakim Bouyahya, ... Imane Chamkhi, in, Ajuga remota Benth. Matkowski & Piotrowska (2006) included Stachys officinalis in their research into the antioxidant activity of several medicinal herbs. Ajuga (zhivuchka in Russian), a genus of plants of the family Labiatae. Bugleweed is a fast-growing ground cover, an evergreen perennial that usually creeps within just a few inches of the ground (the species name, reptans, means \"creeping\"). ajuga. Eighty-three patients with chronic cholecystitis and cholangitis received stachyglen (total flavonoids from the herb Stachys neglecta) for 3–4 weeks and it was found that stachyglen exerts a choleretic effect (Peleshchuk et al 1974). Microglial cells form the praetorium of the brain, which account for the clearance of necrotic neurons and debris in the parenchyma via phagocytosis. The same ratio of activities held at lower concentrations. However, the compound exhibited in vitro cytotoxicity against the A431 human skin carcinoma cell line. Its two known isolates ajugarin-1 and ergosterol-5,8-endoperoxide and a new isolate 8- O -acetylharpagide were evaluated for their in vitro antiplasmodial activity. It is a small herbaceous plant (5 at 20 cm in height) known locally in Morocco and Algeria as “Chondgoura” or “Chendghoura” (Miara et al., 2013) and in North-eastern Sahara as “Toutoulba” (Kemassi et al., 2014). A. iva is distributed in the North African and South European countries (Israili and Lyoussi, 2009). It is invasive in parts of North America. Phytochemical characterization could also serve as a base for the development of new chemical compounds. There is little research available to support this. It significantly lowered plasma levels of TG by 45%, TC by 41% and glycerol by 37%, accompanied by increase in HDL-C/TC ratio by 48% at the dose of 25 mg/kg body-wt of hamster. In a streptozotocin animal model, A. nipponensis had the best effect, decreasing postprandial blood glucose concentrations and inhibiting α-glucosidase and glucose uptake (Hsieh et al., 2014). The volatile oils of eight species of Stachys growing in Greece were tested against six bacteria and five fungi, and Stachys scardica was the most effective, but, as in many studies, no oil inhibited growth of Pseudomonas aeruginosa (Skaltsa et al 2003). In vitro pharmacological studies have been conducted on constituents of A. remota of which some of them displayed a concentration-dependent inhibition of chloroquine-sensitive and -resistant Plasmodium falciparum and Mycobacterium tuberculosis. Bulga Kuntze. =Ajuga integrifolia var. Larval susceptibility of Ajuga remota against anopheline and culicine mosquitos. The structural similarity with statin like lovastatin allowed the comparison, and suggested that 40 might act through inhibition of HMGR as statins. can be used not only in the treatment of diabetes but also in the prevention and treatment of hypercholesterolemia. Further molecular docking studies using FlexX program demonstrated that it docked well into the same pocket that accommodates statin inhibitors. 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