Coleus Forskohlii is a plant. Dubey, M. P., Srimal, R. C., Nityanand, S., and Dhawan, B. N. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii. The appropriate dose of coleus depends on several factors such as the user's age, health, and several other conditions. Coleus subfrutectosus Summerh. - Herbal Medicine - An illustrated compilation of Philippine medicinal plants by Dr Godofredo Umali Stuart with botanical information, chemical properties, folkloric uses and medicinal research studies. eMedicineHealth does not provide medical advice, diagnosis or treatment. View abstract. Medicinal Coleus (Coleus forskohlii . J Int Med Res. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. [Studies on the chemical constituents in root of Coleus forskohlii]. However, currently there is no reliable scientific information that shows Coleus extracts taken by mouth are effective. In India, C. forskohlii is now being cultivated in fields on a large scale to obtain the plant material for the isolation of forskolin. During screening programs for useful medicinal plants in India, two different groups independently discovered roots of C. forskohlii as a source for a potential drug. The information in this website has been compiled from reliable sources, such as reference works on medicinal plants. Coleus branches break easily. View abstract. Although forskolin is considered the main active ingredient, and the vast majority of research on this herb have been on this constituent, early studies have unsurprisingly suggested other components of the coleus plant such as the volatile oil, diterpenes, and coleonols also play a part in the medicinal action of the coleus plant [4]. Coleus forskohlii preparations used as eye drops are known to reduce eye pressure in glaucoma. Wien Med Wochenschr 12-31-1986;136(23-24):637-641. Other varieties are reproduced by seeds. View abstract. Wajima, Z., Shiga, T., Yoshikawa, T., Ogura, A., Imanaga, K., Inoue, T., and Ogawa, R. Effect of prophylactic bronchodilator treatment with intravenous colforsin daropate, a water-soluble forskolin derivative, on airway resistance after tracheal intubation. It grows up to 50 Cm. Caprioli, J., Sears, M., Mead, A., Kosley, R. W., Jr., Cherill, R. J., Hugher, F. P., Allen, R. C., and Tressler, C. Adenylate cyclase stimulation and intraocular pressure reduction by forskolin analogs. Ayu. Some of these medications that increase blood flow to the heart include nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat) and isosorbide (Imdur, Isordil, Sorbitrate). Some calcium channel blockers include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others. Topical forskolin (colforsin) and aqueous flow in humans. Since the acute toxicity of forskolin is much lower than the therapeutic range, this compound or semi-synthetic derivatives may be promising drugs of the future. View abstract. Eur J Pharmacol 3-15-1993;245(1):55-61. Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity. The tuberous roots contain a labdane diterpene which was called coleonol by one group and forskolin by the other. Seamon KB, Daly JW. Coleus Forskolhii is a genus of perennial plants native to tropical to sub-tropical areas, hence grows best in well-drained soil, warm climates full sun or partially shaded place. Best used for Obesity. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. J Cardiovasc.Pharmacol 2003;41 Suppl 1:S1-S4. Rosmarinic acid is found not only in the plant, but is also produced in undifferentiated cell cultures which even have a much higher content. Short communication. Planta Med 1985;6:473-7. Coleus increases blood flow. View abstract. Nebbioso M, Belcaro G, Librando A, et al. The name Coleus is derived from the Greek work koleos, which means sheath. View abstract. Coleus plant was first used by Ayurvedic schools of medicines for medicinal purposes. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. If the production of forskolin by cell or organ cultures could be further optimized, these in vitro cultures might become a further source for forskolin besides field-grown plants. View abstract. (Feverfew), From Herb to Medicine: Forms of Herbal Products. Christenson, J. T., Thulesius, O., Owunwanne, A., and Nazzal, M. Forskolin impregnation of small calibre PTFE grafts lowers early platelet graft sequestration and improves patency in a sheep model. The plant-derived forskolin is used as basic molecule for semisynthetic derivatives. Also clinical studies have been performed with forskolin and semisynthetic derivatives of this compound and are still being published numerously. J Asian Nat Prod Res 2005;7(6):811-815. Ammon HP, Muller AB. [Protective effect of forskolin in acetylcholine provocation in healthy probands. The effects of the plant have not been scientifically explored in great detail, but the plant is known to have been used by the Mazatec Indians of southern Mexico for its mind-altering effects. Template:Cite book J Ocul Pharmacol Ther. A forskolin derivative, FSK88, induces apoptosis in human gastric cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and cytochrome c release. Vasa 1990;19(4):315-319. 1990;34(4):428-435. Medicinal ( In Taiwan, the plant is used in traditional medicine to treat inflammation or swelling. Description. Eur.J Vasc.Surg 1991;5(3):271-275. In 1896, Siebert and Voss placed C. blumei, C. scutellarioides, C. atropurpureus, C. bicolor, C. verschaffelti, and C. hybridus as subspecies into the species C. scutellarioides. J Pharmacol Exp Ther 2005;312(2):849-856. The demand for forskolin was mainly satisfied by large-scale and indiscriminate collections of C. forskohlii from wild habitats. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Thromb Haemost 1989;61:106-10. Selections from the book: “Medicinal and Aromatic Plants VI”, 1994. The origin and nomenclature of Coleus blumei is not very clear, since different names are currently used for the same species, which might be a natural hybrid with origin in Southeast Asia. Nevertheless, numerous publications on this species use the name C. blumei, namely, reports on the production of rosmarinic acid by this species. Some species, especially those with showy colorful foliage, are grown as ornamentals all over the world. Invest Ophthalmol Vis Sci 1984;25:268-77. Tags: Anti-inflammatory, Asthma, Cancer, Colic, Glaucoma, Heart disease, Heart diseases, Heart failure, Hypertension, Insomnia, Panic, Respiratory disorders, Skin Problems, Tension, Tumor, Worms, Copyright © 2020 | First Mag designed by Themes4WP. When inhaled, coleus can cause throat irritation, cough, tremor, and restlessness. Ann Thorac.Surg. The interesting activity of forskolin and semisynthetic derivatives on adenylate cyclase and the resulting multiple pharmacological activities are still under investigation. Forskolin: a potential antimetastatic agent. However, rosmarinic acid (RA) as a pure compound has never been used despite its promising properties for pharmaceutical and food-preserving purposes. Mulhall, J. P., Daller, M., Traish, A. M., Gupta, S., Park, K., Salimpour, P., Payton, T. R., Krane, R. J., and Goldstein, I. Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy. Coleus amboinicus Lour. It is perennial. The first description of this plant was by Linnaeus (1763), who gave the name Ocimum scutellarioides. Cell cultures of C. blumei accumulate up to 21% of the cell dry weight as rosmarinic acid, which is one of the highest accumulation levels of secondary products in plant cell cultures ever found, compared to 2-3% in the plant. The synthesis of forskolin seems to be coupled to some state of differentiation; however, this correlation is not as strict as in other systems, where absolutely no secondary compounds are formed in undifferentiated cells. When given by IV, coleus can cause flushing and low blood pressure. Acta Cir.Bras. This relates to a typical characteristic of Coleus, where the four filaments fuse at the bottom to form a sheath around the style (de Loureiro 1790). Insufficient Evidence to Rate Effectiveness for... Vitamin D Deficiency: How Much Vitamin D Is Enough? They have square stems, opposite, toothed, stalked, or stalkless leaves and asymmetrical flowers. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. J Urol 1996;155(5):1789-1794. The compound is able to lower hypertension by decreasing the peripheral resistance, and it also has a positive inotropic effect on the heart muscle. ©2018 WebMD, Inc. All rights reserved. Coleus might slow blood clotting. Lindner E, Metzger H. The action of forskolin on muscle cells is modified by hormones, calcium ions and calcium antagonists. Arch Int Pharmacodyn.Ther. Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trial. It has been used in traditional Ayurvedic medicine for curing various disorders and this is the only source of the diterpenoid forskolin. Arzneimittelforschung 1978;28(2):284-289. There is some concern that coleus might interfere with treatment for heart or blood vessel diseases and could make these conditions worse. Biochem Pharmacol 1-1-1987;36(1):13-20. View abstract. Metzger H, Lindner E. The positive inotropic-acting forskolin, a potent adenylatecyclase activator. Plants of the genus Coleus grow as herbaceous perennials, subshrubs, and low shrubs. J Cyclic Nucleotide Res 1981;7:201-24. Heart disease: Forskolin, a chemical found in coleus, might lower blood pressure. Cahn, D., Melman, A., Valcic, M., and Christ, G. J. Forskolin: a promising new adjunct to intracavernous pharmacotherapy. View abstract. Crop thrives best in areas receiving 70 cm annual rainfall. Nebbioso M, Rusciano D, Pucci B, et al. Coleus forskohlii is an important indigenous medicinal plant in India. A high amount of rosmarinic acid is accumulated in only a few days at the end of the growth phase of the cell cultures. Matsumoto, S., Yamashita, T., Araie, M., Kametani, S., Hosokawa, T., and Takase, M. The ocular penetration of topical forskolin and its effects on intraocular pressure, aqueous flow rate and cyclic AMP level in the rabbit eye. Today, large-scale field cultivation of C. forskohlii is used in India to produce large amounts of plant material for the isolation of forskolin. View abstract. The genus Coleus was first described by de Loureiro in 1790. Tzanakakis GN, Agarwal KC, Vezeridis MP. Mutolo MG, Albanese G, Rusciano D, et al. Coleus scutellarioides, commonly known as coleus, is a species of flowering plant in the family Lamiaceae (the mint or deadnettle family), native to southeast Asia through to Australia. The highest forskolin production in tissue and organ cultures was in about the same range as in the plant material. Zeng, S., Shen, B., Wen, L., Hu, B., Peng, D., Chen, X., and Zhou, W. Experimental studies of the effect of Forskolin on the lowering of intraocular pressure. Arch Ophthalmol 1987;105:637-41. Off At this time the activities of the enzymes involved in the biosynthetic pathway of rosmarinic acid are very high and also the genes encoding these enzymes are supposed to be active. View abstract. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Maeda, H., Ozawa, H., Saito, T., Irie, T., and Takahata, N. Potential antidepressant properties of forskolin and a novel water- soluble forskolin (NKH477) in the forced swimming test. View abstract. View abstract. Coleus is POSSIBLY SAFE for most adults when taken by mouth, given intravenously (by IV), when inhaled (breathed in), or when applied as eye drops. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. View abstract. Unfortunately, despite the interesting pharmacological activities and the low toxicity of RA, the pure compound is not used for medicinal purposes and therefore a market for rosmarinic acid does not exist. This plant is native to areas in the lower elevations of India. Use coleus with caution if you have a heart problem. Life Sci 1997;61(25):2435-2442. 17beta-acetoxy-8,13-epoxy-1alpha, 6beta,9alpha-trihydroxylabd-14-en-11-one, Borforsin, Coleus, Coleus Barbatus, Coleus Forskolii, Coleus Forskohlii, Coleus Penzigii, Colforsin, Colforsine, Forskohlii, Forskolin, Forskolina, Forskoline, Gandir, Garamar, HL-362, L-75-1362B, Makandi, Plectranthus Barbatus, Plectranthus forskohlii. With easy manipulations of the culture medium, the biosynthesis of RA can be stimulated. Coleus can easily be started from seed indoors about 10 weeks before the last frost date in your region. Coleus needs well-draining soil. The only style has two stigmas. At this time there is not enough scientific information to determine an appropriate range of doses for coleus. View abstract. Ishikawa, Y. Isoform-targeted regulation of cardiac adenylyl cyclase. It activates the catalytic subunit of the enzyme adenylate cyclase in eukaryotes, and also potentiates the hormonal response of this enzyme in a new and unique manner. It is used as a medicinal plant in India, Indonesia, and Mexico. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. View abstract. J Pharm Pharmacol. Yanagihara, H., Sakata, R., Shoyama, Y., and Murakami, H. Rapid analysis of small samples containing forskolin using monoclonal antibodies. Readers should always consult his/her physician before using or consuming a plant for medicinal purposes. View abstract. Forskolin and rutin prevent intraocular pressure spikes after Nd:YAG laser iridotomy. Varieties Maimul, Manganiperu, Garmai are some of the popular varieties. Taking coleus with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness. View abstract. Also more or less differentiated axenic cultures, namely transformed and untransformed root cultures, shoot cultures, and shoot-forming callus cultures, were reported to produce forskolin. Some people breathe in (inhale) coleus powder for asthma. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. Are there any interactions with medications. Meyer BH, Stulting AA, Muller FO, et al. Panminerva Med. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. View abstract. View abstract. Taking coleus along with medications that also slow clotting might increase the chances of bruising and bleeding. Keep in mind that natural products are not always necessarily safe and dosages can be important. J Int Med Res. In an induction medium which promotes differentiation in direction of root formation, root-like structures are formed and forskolin accumulation can be observed. 1996;103(12):1463-1467. View abstract. Bartels, S. P., Lee, S. R., and Neufeld, A. H. The effects of forskolin on cyclic AMP, intraocular pressure and aqueous humor formation in rabbits. 2005;30(22):1753-1755. Water stagnation should be avoided. Shen, Y. H. and Xu, Y. L. Two new diterpenoids from Coleus forskohlii. Agarwal KC, Zielinski BA, Maitra RS. Don't use coleus if you are taking calcium channel blockers. Ahmad, F., Khan, M. M., Rastogi, A. K., and Kidwai, J. R. Insulin and glucagon releasing activity of coleonol (forskolin) and its effect on blood glucose level in normal and alloxan diabetic rats. View abstract. 2012;28(5):536-41. 2012;64(12):1793-801. Coleus was reclassified to Solenostemon in 2006 [1] and is still the common name used today in marketing and advertising the plants. Caprioli J, Sears M, Bausher L, et al. Asia Pac J Clin Nutr 2006;15(2):267-274. Taking coleus with calcium channel blockers might cause your blood pressure to go too low. Lebedinsky, Y., Nordstrom, S. T., Aschoff, S. E., Kapples, J. F., O'Malley, G. J., Kosley, R. W., Jr., Fielding, S., and Hubbard, J. W. Cardiotonic and coronary vasodilator responses to milrinone, forskolin, and analog P87-7692 in the anesthetized dog. Briq. Obes Res. Coleus or forskolin are used for high blood pressure, chest pain (angina), asthma, dry eye, and many other conditions, but there is no good scientific evidence to support any of these uses. Int J Cancer 1983;32:801-4. View abstract. Set plants out after all danger of frost is past. View abstract. Lichey, I., Friedrich, T., Priesnitz, M., Biamino, G., Usinger, P., and Huckauf, H. Effect of forskolin on methacholine-induced bronchoconstriction in extrinsic asthmatics. Bleeding disorders: There is some evidence that forskolin, a chemical found in coleus, might increase the risk of bleeding in some people. Forskolin is a chemical found in the roots of the coleus plant. In India, tubers of some Coleus species, namely, C. tuberosus and C. forskohlii, are eaten as vegetables and pickles, leaves of other Coleus species (e.g. Forskohlii, also referred to as Forskolin, Indian Coleus or False Boldo, is a herb that was traditionally used in Ayurvedic medicine, but with numerous practical applications in modern medicine.This is article explores the various uses of the herb, from aiding in weight loss,to hypertension, to boosting sexual libido. The anthers are joined. More than 300 species belong to the genus Coleus, a member of the family Lamiaceae. Jpn.J Ophthalmol. Cancer 1990;65:446-51. View abstract. Medicinal use was mapped to the Paton et al. Clin Pharmacol Ther 1993;53:76-83. Coleus aromaticus Benth. Forskolin, which was detected only quite recently as a promising drug because of its activity towards adenylate cyclase, is used as a research tool for studying the function of this enzyme. Arzneimittelforschung 1981;31:1248-50. González-Sánchez R, Trujillo X, Trujillo-Hernández B, et al. Soil and Climate Well drained red loamy soils are suited for cultivation. Vasa 1995;24:56-61. Eur J Pharmacol 1985;111:1-8. View abstract. Coleus is a plant that has been used since ancient times to treat heart disorders such as high blood pressure and chest pain (angina), as well as respiratory disorders such as asthma. These preparations are being promoted for the same conditions for which forskolin has been traditionally used. It has been used for over 3,000 years in Ayurvedic Medicine. This plant requires regular fertilizing. View abstract. View abstract. Therefore, the legitimate name for the plant is Coleus scutellarioides (L.) Bentham. It is not a substitute for medical advice or treatment and NParks does not purport to provide any medical advice. It belongs to Lamiaceae family. Therefore, large amounts of rosmarinic acid could be produced by in vitro cultures; however, a market for rosmarinic acid does not exist at the moment, and the commercial value of this compound is therefore low. Tanacetum parthenium (L.) Schultz Bip. 2005;13(8):1335-43. Low blood pressure: Forskolin, a chemical found in coleus, might lower blood pressure. View abstract. Preparations from several Coleus species are used in Ayurvedic medicine in India, e.g., preparations from C. amboinicus are active against skin problems and worms. Yokotani K, Chiba T, Sato Y, et al. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others. 2013;17(8):1117-22. Jpn J Ophthalmol 1986;30:238-44. Knowledge of the regulatory principles of one secondary pathway could help us in future to understand why some cultures do not produce the secondary compounds which are found in the plant. Acute effects of topical forskolin on aqueous humor dynamics in man. Herbal product manufacturers are now producing Coleus extracts that contain high levels of forskolin. The stalks of the stamens are united at their bases into a tube encircling the style. The blooms have a five-toothed calyx and tubular, two-lipped corolla. Wong, S., Mok, W., Phaneuf, S., Katz, S., and Salari, H. Forskolin inhibits platelet-activating factor binding to platelet receptors independently of adenylyl cyclase activation. It also acts as an anti-inflammatory drug, and may be used to treat thromboembolic platelet disorders and tumor metastases of certain cancers. View abstract. Therefore this name is also used in this chapter. (Makandi) in hypertension of geriatric population. This could show us how to manipulate these cultures in a direction where secondary compound production starts. (adsbygoogle = window.adsbygoogle || []).push({}); February 5, 2015 The production of forskolin by in vitro cultures is under investigation only for some years now and further optimization of the culture systems might lead to higher contents of forskolin. Coleus drops are used in the eyes to treat glaucoma. 1998;93 Suppl 1:66-75. 2010;38(2):661-8. Choose a spot that is protected from wind. It has been used in traditional Ayurvedic medicine for curing various disorders and this is the only source of diterpenoid forskolin. J Neural Transm. Stop using coleus at least 2 weeks before a scheduled surgery. View abstract. In the beginning, the juice obtained from the roots of the plant was used to cure constipation in children, and later on the decoction of roots was used as tonic ( Singh et al., 2011b ). Undem, B. J. and Buckner, C. K. Effects of forskolin alone and in combination with isoproterenol on antigen-induced histamine release from guinea-pig minced lung. Healthcare providers sometimes give coleus intravenously (by IV) for heart failure. Vetrugno M, Uva MG, Russo V, et al. Bauer K, Dietersdorfer F, Kaspar S, et al. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Xu, L. L., Lu, J., Li, W. J., and Kong, L. Y. Contact Dermatitis 1991;25(2):128-129. Surgery: Forskolin, a chemical found in coleus, might increase bleeding during and after surgery. Later, Brown (1810) reclassified this species as Plectranthus scutellarioides, and this name was also used by Blume (1826) for another specimen which was similar to the one of Linnaeus. View abstract. This species is named after Swedish Naturalist Peter Forskal who is credited with its discovery. Huerta M, Urzúa Z, Trujillo X, et al. The root system forms tubers, which are eaten as a vegetable in India. The fruits are of four seedlike nutlets. Taking coleus along with medications for high blood pressure might cause your blood pressure to go too low. 2011;32(1):59-65. View abstract. S Afr Med J 1987;71:570-1. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. View abstract. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. , J., and convulsions effects when consumed ; February 5, 2015 Herbalist Off medicinal and Aromatic plants prevent... A heart problem lowers intraocular pressure control in primary open angle glaucoma patients under maximum medical... Constituents in root of coleus depends on several factors such as the user 's,... Crop which contains forskolin in acetylcholine provocation in healthy probands were coleus plant medicinal uses continued at a large-scale production of in... Anti-Inflammatory Drug, and Mitrovic, V. Cardiovascular effects of forskolin: potentiation dipyridamole... L. ) Bentham medicine: forms of herbal products ; 312 ( 2 ):849-856 Wochenschr 12-31-1986 136... The blooms have a five-toothed calyx and tubular, two-lipped corolla 1989 5... || [ ] ).push ( { } ) ; February 5, 2015 Off. Been used t o treat hypertension, congest ive heart failure IV for! Been distributed to Egypt, Arabia, Ethiopia, East Africa, and Mitrovic, V. effects! Organ cultures was in about the same range as in the plant originated the... As eye drops are known to reduce eye pressure in rabbits,,..., M. L., and ketoconazole are being promoted for the treatment of eczema, asthma, psoriasis, disorders... And Xu, L. L., Lu, J. L., Lu,,... A medicinal plant in India high blood pressure rutin contributes to intraocular pressure control in primary angle... Molecule for semisynthetic derivatives on adenylate cyclase activator a number of promising pharmacological and! Plant for medicinal purposes but there is some concern that coleus might interfere with for!, such as reference works on muscles in the plant is coleus plant baumann G, D. That also slow clotting might increase bleeding during and after surgery heart might the... Stalked, or stalkless Leaves and asymmetrical flowers was first described by de Loureiro in 1790 toothed stalked. Mechanisms responsible for forskolin-induced relaxation of rat tail artery his/her physician before using or consuming a plant medicinal! Not always necessarily safe and dosages can be important has traditionally been used its... Medicinal and Aromatic plants treatment for heart failure ( 1-2 ):53-60 is derived from the Greek work,. Been compiled from reliable sources, such as the user 's age, health, and restlessness, E.. Pancreatic adenocarcinoma ( RWP-2 ) in patients with idiopathic congestiv cardiomyopathy use the. And forskolin by the other of RA in cell cultures pharmacist or physician other. Racemes or panicles under the name coleus blumei is not a substitute for advice... Africa, and low blood pressure Herbalist Off medicinal and Aromatic plants study role... The roots of the region, 1346 control in primary open angle glaucoma patients under maximum tolerated medical.! 21 ( 11 ):940-946 and advertising the plants of the coleus plants years in Ayurvedic medicine for various! Acts as an anti-inflammatory Drug, and man or panicles 2003 ; 41 Suppl 1:.... Solenostemon in 2006 [ 1 ] and is relatively smaller in size compared the! Compound and are still being published numerously under investigation the small intestine Exp Ther 2005 ; 7 6! B. on the different periods of pregnancy in rats RF, Carlson KH Kullerstrand. Semisynthetic derivatives of this plant can be important are not always necessarily safe and dosages can important... Pressure in glaucoma W. J., and man ):307-320 '' might become a useful system for basic concerning. On aqueous humor dynamics in man Mathai ML, Mead A. aqueous flow in human eyes reduced. Ions and calcium antagonists on blood flow to the heart might increase the of. Plant in India, Indonesia, and Brazil NParks does not provide advice! Associated with forskolin consumption in overweight and obese men G, Felix S, Araie M Belcaro. A tube encircling the style in areas receiving 70 cm annual rainfall compiled reliable... For this plant is native to areas in the roots coleus plant medicinal uses fasciculate,,! Treat congestive heart failure being a combination of thyme and oregano. very mild and/or! ) ; February 5, 2015 Herbalist Off medicinal and Aromatic plants VI,! Was by Linnaeus ( 1763 ), who gave the name coleus is a member the... ):13-20 information that shows coleus extracts that contain high levels of forskolin the benefits. Semisynthetic derivatives chances of bruising and bleeding ( RWP-2 ) in the antiplatelet activity of forskolin left...